Inherited Diseases of Children and Adults Program
We are on a mission to develop the technology and approaches needed to interpret everyone鈥檚 genetic code. Currently, most genetic differences lack a medical or biological interpretation. Therefore, collaborating with national and international researchers, clinicians, patients, and students, the Mellowes Institute聽seeks to advance multidisciplinary research, leveraging structural and functional genomics, structural bioinformatics, and epigenetics to discover the pivotal role that specific genes have in the pathobiology of rare diseases. Evidenced by an extensive publication record, our integrative and holistic approach sets our program apart and shapes the future of genomic data interpretation.
The Mellowes Institute, through its partnership with the , is a .听We connect to Children鈥檚 Wisconsin Quantitative Health Sciences via our Director of Child Health Bioinformatics. Regionally, this program connects with multiple Midwest institutions to form a rare disease research federation. Finally, our faculty partner with physicians and researchers around the world to explore diverse patient cases and offer 鈥極mics and Bioinformatics services to researchers through our shared resource units.
Program Faculty
Donald G. Basel, MD
Section Chief and Professor, Pediatrics (Genetics); Associate Director, Undiagnosed & Rare Diseases, Linda T. and John A. Mellowes Institute for Genomic Medicine and Precision Therapeutics; Medical Director, Genetics Center, Children鈥檚 Wisconsin; Co-program Director, Neurofibromatosis and RASopathy, Children's Wisconsin
Jing Dong, PhD
Assistant Professor
Xiaowu Gai, PhD
Linda T. and John A. Mellowes Endowed Chair in Systems Biology; Professor, Pediatrics; Division Chief, Bioinformatics and Quantitative Child Health; Director, Child Health Bioinformatics; Associate Director, Linda A. and John T. Mellowes Institute for Genomic Medicine and Precision Therapeutics
Angela J. Mathison, PhD
Associate Professor, Department of Surgery; Technology Development Director, Linda T. and John A. Mellowes Institute for Genomic Medicine and Precision Therapeutics
Brian Smith, PhD
Associate Director, Program in Chemical Biology; Professor, Biochemistry
James Verbsky, MD, PhD
Professor, Pediatrics (Rheumatology) and Microbiology & Immunology; Medical Director, Clinical Immunology Research Laboratory; Medical Director, Clinical and Translational Research
Brian F. Volkman, PhD
Director, Program in Chemical Biology; Professor, Biochemistry
Michael T. Zimmermann, PhD
Director, Computational Structural Genomics Unit and Associate Director, Computational Biology, Linda T. and John A. Mellowes Institute for Genomic Medicine and Precision Therapeutics; Associate Professor, Data Science Institute
Inherited Diseases Sample Publications
. Haque N, Kawai T, Ratnasinghe BD, Wagenknecht JB, Urrutia R, Notarangelo LD, Zimmermann MT. iScience. 2023 Sep 27;26(10):108040. doi: 10.1016/j.isci.2023.108040. eCollection 2023 Oct 20.PMID: 37854700
. Cousin MA, et al. Genome Med. 2022 Jun 13;14(1):62. doi: 10.1186/s13073-022-01064-4.PMID: 35698242
. Delmonte OM, Bergerson JRE, Kawai T, Kuehn HS, McDermott DH, Cortese I, Zimmermann MT, Dobbs AK, Bosticardo M, Fink D, Majumdar S, Palterer B, Pala F, Dsouza NR, Pouzolles M, Taylor N, Calvo KR, Daley SR, Velez D, Agharahimi A, Myint-Hpu K, Dropulic LK, Lyons JJ, Holland SM, Freeman AF, Ghosh R, Similuk MB, Niemela JE, Stoddard J, Kuhns DB, Urrutia R, Rosenzweig SD, Walkiewicz MA, Murphy PM, Notarangelo LD. Blood. 2021 Sep 23;138(12):1019-1033. doi: 10.1182/blood.2020008629.PMID: 33876203