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Physiology
Curt Sigmund

Curt D. Sigmund, PhD

James J. Smith & Catherine Welsch Smith Professor of Physiology; Chair of Physiology

Locations

  • Basic Science Building
    573A

Contact Information

Learn more about the Curt Sigmund Laboratory

Biography

Dr. Sigmund is the James J. Smith & Catherine Welsch Smith Chair of Physiology at the 成人快手. Dr. Sigmund previously served as Professor and Roy J. Carver Chair in Hypertension Research; Director, Chair and Department Executive Officer, Department of Pharmacology; UIHC Center for Hypertension Research at the Roy J. and Lucille A. Carver College of Medicine at the University of Iowa. He has published over 250 papers, chapters, and reviews and has trained over 50 PhD students and postdoctoral fellows many of whom hold research and faculty positions nationally and internationally. He has held numerous leadership roles in prominent societies. He recently was elected to serve a two-year term as the new Chair-Elect of the American Heart Association Council on Hypertension and is currently the Chair of the Publications Committee of the American Physiological Society (APS). He was previously Associate Editor and Editor-in-Chief for several APS journals. He served on the External Scientific Review Board of the 成人快手 Cardiovascular Center (now the Cardiovascular Research Center) from 2016-2017 and served as its Associate Director.

Research Interests

Dr. Sigmund’s major areas of research focus on central nervous system and vascular mechanisms of blood pressure regulation by the renin-angiotensin system, the transcription factor PPAR-gamma, and its downstream effectors Cullin-3/RhoBTB1, investigating these using a combination of molecular biological, genetic and physiological approaches including the generation of unique transgenic and knockout models. Dr. Sigmund’s laboratory is located within the Cardiovascular Research Center in the Health Research Center and Medical Education buildings.

Publications

  • (Mathieu NM, Lawton SBR, Dorrington MM, Grobe CC, Hole VW, Wackman KK, Bordas-Murphy H, Freed JK, Segar JL, Nakagawa P, Sigmund CD, Mouradian GC Jr, Grobe JL, Reho JJ.) Am J Physiol Regul Integr Comp Physiol. 2026 Oct 01 PMID: 42821472 10/01/2026

  • (Tvina AL, Livergood MC, Kumar G, Hole VW, Opichka MA, Irizarry LM, Lu KT, Wackman KK, Grobe JL, Nakagawa P, McIntosh JJ, Sigmund CD.) Physiol Rep. 2026 Aug;14(15):e71039 PMID: 42552612 PMCID: PMC13437954 SCOPUS ID: 2-s2.0-105046601065 08/05/2026

  • (Grobe CC, Hamilton AJ, Treesukosol Y, Grobe JL, Segar JL, Sigmund CD.) Hypertension. 2026 Aug;83(8):e27127 PMID: 42220234 PMCID: PMC13256247 SCOPUS ID: 2-s2.0-105040585806 06/01/2026

  • (Nakagawa P, Lu KT, Reho JJ, Ghobrial M, Kaminski K, Hantke-Guixa A, Mathieu NM, Brozoski DT, Chaihongsa N, Wackman KK, Rajendiran NR, Dhoondia Z, Segar JL, Sigmund CD, Grobe JL.) Physiol Rep. 2026 Jul;14(14):e71023 PMID: 42473193 PMCID: PMC13382158 SCOPUS ID: 2-s2.0-105045172165 07/20/2026

  • (Kumar G, Chaihongsa N, Brozoski DT, Golosova D, Vazirabad I, Lu KT, Wackman KK, Singh RK, Sigmund CD.) JCI Insight. 2026 Jun 08;11(11) PMID: 41926228 PMCID: PMC13313548 SCOPUS ID: 2-s2.0-105042139589 04/02/2026

  • (Palzkill VR, Moparthy D, Yang Q, Choi J, Liu X, Kim K, Appu AB, Pass CG, Berceli SA, Sigmund CD, Scali ST, Kopinke D, Ryan TE.) Circulation. 2026 May 12;153(19):1477-1493 PMID: 41804775 PMCID: PMC13002131 SCOPUS ID: 2-s2.0-105038580868 03/10/2026

  • (Opichka MA, Livergood MC, Balapattabi K, Ritter ML, Sigmund CD, Kwitek AE, Grobe JL, McIntosh JJ.) Physiol Genomics. 2025 Nov 01;57(11):629-637 PMID: 40983484 PMCID: PMC12616666 SCOPUS ID: 2-s2.0-105018712698 09/23/2025

  • (Ghobrial M, Gomez RA, Grobe JL, Sigmund CD, Nakagawa P.) Endocrinology. 2025 Sep 08;166(10) PMID: 40845152 PMCID: PMC12418094 SCOPUS ID: 2-s2.0-105015546789 08/22/2025

  • (Golosova D, Kumar G, Lu KT, Muskus Veitia PC, Hantke Guixa A, Wackman KK, Fekete EM, Brozoski DT, Grobe JL, Sequeira-Lopez MLS, Gomez RA, Nakagawa P, Sigmund CD.) JCI Insight. 2025 Aug 08;10(15) PMID: 40627460 PMCID: PMC12333948 SCOPUS ID: 2-s2.0-105013217775 07/08/2025

  • (Pasos J, Wagner VA, Lawton SBR, Madison AM, Nandani K, Mathieu NM, Grobe CC, Reho JJ, Freudinger BP, Sherman AJ, Brozoski DT, Morselli LL, Burnett CML, Segar JL, Nakagawa P, Sigmund CD, Grobe JL.) Iscience. 18 July 2025;28(7) SCOPUS ID: 2-s2.0-105007661529 07/18/2025

  • (Golosova D, Kumar G, Chaihongsa N, Reho JJ, Lu KT, Brozoski DT, Wackman KK, Lawton SBR, Muskus PC, Lin BL, Grobe JL, Nakagawa P, Sigmund CD.) Hypertension. 1 July 2025;82(7):1208-1220 SCOPUS ID: 2-s2.0-105005164668 07/01/2025

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