成人快手

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Research Bench Lab
Microbiology & Immunology
Demin Wang, PhD

Demin Wang, PhD

Senior Investigator, Versiti Blood Research Institute; Professor

Locations

  • Microbiology & Immunology

Contact Information

General Interests

Signal Regulation of B Lymphopoiesis

Education

PhD, Biochemistry, University of Tennessee, 1995

Research Interests

During hematopoiesis, hematopoietic stem cells (HSCs) give rise to all blood cells, including erythroid, myeloid and lymphoid lineages. The self-renewal and hematopoietic differentiation of HSCs are strictly controlled by both extrinsic and intrinsic signals. B cells, a subtype of lymphoid cells, are critical to the immune defense, and their development and function are also highly regulated by signals derived from a variety of cell surface receptors. Abnormal signals from the receptors often lead to hematological and immunological diseases, including hematopoietic malignancies, and immunodeficiency and autoimmune diseases. Our research focuses on identifying and functionally characterizing signaling pathways that control B cell development from hematopoietic stem cells (HSCs) and B cell function. Our research employs multiple cutting-edge approaches, including targeted gene disruption, transgenic, bone marrow transplantation and high-throughput DNA/RNA sequencing technologies.

Cytokine receptor signaling

Upon binding of cytokines, cytokine receptors initiate signals to regulate a variety of cellular responses, including cell growth, survival, differentiation, and function during hematopoiesis. Engagement of cytokine receptors induces the activation of the JAK family of cytoplasmic protein tyrosine kinases. In turn, Jaks activate components of diverse signal transduction pathways, including members of the Signal Transducers and Activators of Transcription (Stat). The importance of the JAKs and Stats in signaling has been emphasized by gene disruption studies. Dysregulation of JAK/Stat pathway has been implicated in the pathogenesis of numerous hematological diseases. One of our current research projects studies the regulation and function of Stat proteins.

B cell receptor signaling

B cells are one important component of the adaptive immune system. Signals from the B cell antigen receptor (BCR) and its surrogate predecessor pre-BCR are essential for the development, maintenance and function of B cells. Improper signals from pre-BCR/BCR often result in immunodeficiency, autoimmunity, and B-cell leukemia. During last decade, a wide variety of signaling molecules involved in BCR function have been discovered. Our current research projects aim to fully understand the pre-BCR/BCR signal transduction cascade by identifying novel signaling molecules of the pre-BCR/BCR and investigate the roles of these signaling molecules in pre-BCR/BCR-mediated B cell development and function in vivo.

The long term goals of our research program aim to establish a thorough understanding of the normal signaling pathways of the cytokine and pre-BCR/BCR receptors, to obtain new clues regarding the molecular pathogenesis of numerous hematological and immunological diseases, including acute or chronic hematopoietic malignancies, and immunodeficiency (such as agammaglobulinemia and common variable immunodeficiency) and autoimmune (such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes, multiple sclerosis, hemolytic anemia, and heparin-induced thrombocytopenia) diseases, and to aid in the development of novel therapeutic strategies for treatment of these hematological and immunological disorders.

Publications

  • (Yu M, Zhou L, Zhang Y, Zheng Y, Chen Y, Wang DW, Zhu N, Wen R, Wang D.) Blood. 2026 Aug 27;148(9):1175-1190 PMID: 42095895 PMCID: PMC13332704 SCOPUS ID: 2-s2.0-105045884126 05/07/2026

  • (Kanack AJ, Splinter NP, Mauch EE, Tefera L, Gil MR, Jasra S, Goodwin A, Smock KJ, Ahmad H, Ashrani A, Robinson NL, Casanegra AI, Jones CG, Pechauer SM, Yttre E, Aster RH, Kohlhagen MC, Leger RR, Johns G, Murray DL, Zhou L, Wang D, Wen R, Chen D, Pruthi RK, Padmanabhan A.) Am J Hematol. 2026 Aug;101(8):1790-1798 PMID: 42068120 PMCID: PMC13331636 SCOPUS ID: 2-s2.0-105037658156 05/02/2026

  • (Zhou L, Cao A, Zhu W, Villalobos-Garcia D, Marchan M, Curtis B, Rauova L, Poncz M, Aster R, Padmanabhan A, Wang D, Wen R.) Blood. 2026 Jul 02;148(1):115-129 PMID: 42013023 PMCID: PMC13332703 SCOPUS ID: 2-s2.0-105039298083 04/21/2026

  • (Witman N, Yu M, Zhang Y, Gai K, Chen Y, Zhou L, Nguyen C, Zhu W, Zheng Y, Jobe S, Graham MB, Cui W, Wang D, Wen R.) JCI Insight. 2026 Apr 22;11(8) PMID: 41746733 PMCID: PMC13135393 SCOPUS ID: 2-s2.0-105036735992 02/26/2026

  • (Yu M, Wen R, Wang D.) Methods Mol Biol. 2026;3053:111-118 PMID: 42681409 SCOPUS ID: 2-s2.0-105048897272 09/02/2026

  • (Zhou L, Witman ND, Zhu W, Wang D, Wen R.) Methods Mol Biol. 2026;3053:183-202 PMID: 42681414 SCOPUS ID: 2-s2.0-105048893814 09/02/2026

  • (Koo AS, Jia W, Kim SH, Scalf M, Boos CE, Chen Y, Wang D, Voter AF, Bajaj A, Smith LM, Keck JL, Bakkenist CJ, Guo L, Tibbetts RS.) J Biol Chem. 2025 Dec;301(12):110857 PMID: 41489901 PMCID: PMC12702018 SCOPUS ID: 2-s2.0-105022612021 01/06/2026

  • (Zhang Y, Lin D, Zheng Y, Chen Y, Yu M, Cui D, Huang M, Su X, Sun Y, Chen Y, Qian Z, Carlson KS, Wen R, Wang D.) Leukemia. 2023 Nov;37(11):2261-2275 PMID: 37670087 PMCID: PMC10844005 SCOPUS ID: 2-s2.0-85169811460 09/06/2023

  • (Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z.) Res Pract Thromb Haemost. 2023 Aug;7(6):102164 PMID: 37680312 PMCID: PMC10480648 09/08/2023

  • (Zheng Y, Yu M, Chen Y, Xue L, Zhu W, Fu G, Morris SW, Wen R, Wang D.) J Immunol. 2023 May 01;210(9):1222-1235 PMID: 36961449 PMCID: PMC10156913 SCOPUS ID: 2-s2.0-85152627989 03/25/2023

  • (Zhang Z, Dai W, Zhu W, Rodriguez M, Lund H, Xia Y, Chen Y, Rau M, Schneider EA, Graham MB, Jobe S, Wang D, Cui W, Wen R, Whiteheart SW, Wood JP, Silverstein R, Berger JS, Kreuziger LB, Barrett TJ, Zheng Z.) Research and Practice in Thrombosis and Haemostasis. August 2023;7(6) SCOPUS ID: 2-s2.0-85169507694 08/01/2023

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