Sana Parveen, PhD

Postdoctoral Researcher

Biography

Sana Parveen is a postdoctoral researcher in medicine (hematology and oncology) at the 成人快手 (成人快手). She earned her PhD in Cancer Biology from the Centre for Cellular and Molecular Biology (CCMB) in Hyderabad, India, and joined Dr. Hui鈥慫i Chen’s lab in August 2022.

Her doctoral research at CCMB focused on complex interactions among key signaling pathways that regulate eukaryotic mRNA translation, including mTORC1, stress kinases, ERK, and p38 MAPKs. Her work also included characterizing geneticin鈥憆esistant epithelial鈥憈o鈥憁esenchymal transition (EMT) in hepatocellular carcinoma cells through whole鈥憈ranscriptome analysis. She additionally coauthored a review on pharmacologically active compounds derived from marine sources, underscoring her interest in cancer and therapeutic mechanisms.

At 成人快手, her research focuses on elucidating the epigenetic mechanisms underlying lung cancer, particularly those driven by the histone methyltransferase EZH2. EZH2 is highly expressed in small cell lung cancer and plays a central role in chemotherapy and immunotherapy resistance. Her work in Dr. Chen’s lab explores the mechanisms of EZH2 mediated immunotherapy resistance and identifies novel EZH2 regulated gene pathways with potential for therapeutic intervention. During this time, she developed extensive expertise in high鈥憈hroughput next鈥慻eneration sequencing (NGS) techniques and bioinformatics analyses, including RNA鈥憇eq, ATAC鈥憇eq, and Micro鈥慍 (3D genome mapping). In collaboration with Tempus AI, she is currently analyzing real world small cell lung cancer (SCLC) datasets that integrate genomic, transcriptomic, and clinical data to characterize disease heterogeneity and identify predictive biomarkers of treatment response. Alongside her research, she contributes to 成人快手’s Postdoctoral Advisory Committee, helping organize scientific and community鈥慴uilding events for postdocs.

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