Fenlu Zhu, PhD

Assistant Professor

Locations

Hematology and Oncology

Biography

Dr. Fenlu Zhu is an assistant professor of medicine (hematology and oncology) at the 成人快手. He received his PhD degree in molecular biology/virology from the Institute of Basic Medical Sciences in Beijing, China. He completed his post-doctoral fellowship in cellular immunology and started working on immunotherapy in the Blood and Marrow Transplant Laboratories at the 成人快手. He joined the faculty in the Department of Medicine at the 成人快手 in 2017.

Dr. Zhu’s research interest has been focusing on immunotherapy especially preclinical process development and validations; large-scale cGMP manufacturing of cellular products including patient cell purification, expansion, transduction and formulation; product characterization and release testing such as phenotype, potency, purity and stability; technology transfer from research bench to clinical production; quality control, FDA regulations and FACT accreditations; SOP preparation and investigational new drug (IND) applications; immune monitoring and correlative studies pre and after cellular therapy infusion. Pre-clinical process developments have been conducted, INDs have been approved and cellular therapy products have been manufactured under cGMP for clinical trials including manufacturing multi-specific (EBV, CMV and Adenovirus) cytotoxic T lymphocytes (CTL) in G-Rex system and using those cells to treat and prevent viral infections in transplant patients, and development and manufacture of the CD20_CD19 dual chimeric antigen receptor (CAR) T cells using CliniMACS Prodigy Device for the treatment of B cell malignancies.

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